【摘要】 目的:探索进展期乳腺癌术中手术部位植入氟尿嘧啶植入剂化疗的安全性,寻找预防乳腺癌局部复发的新途径。方法:63例Ⅱ期乳腺癌患者随机分为术中植入氟尿嘧啶植入剂组(实验组)和对照组,实验组在胸大肌及腋窝植入氟尿嘧啶植入剂。观察植药后白细胞及丙氨酸氨基转移酶(ALT)、胆红素和肌酐变化,切口引流液的量,皮下积液,局部溃疡及有无淋巴漏等。结果:实验组与对照组的白细胞及ALT、胆红素和肌酐变化,皮下积液,局部溃疡及有无淋巴漏的发生率以及切口引流量差异无显著性;两组术后第1天血白细胞计数、ALT、胆红素和肌酐较治疗前有明显升高(P<0.05),但两组间差异无显著性(P>0.05)。结论:乳腺癌术中植入氟尿嘧啶植入剂安全可靠,是术后局部区域性化疗的有效途径。更多还原

【Abstract】 Objective To investigate the safety of local chemotherapy with fluorouracil implants in patients with breast cancer who were receiving modified radical mastectomy. Methods Sixty-three patients with breast cancer who were to receive modified radical mastectomy were divided into fluorouracil group and control group. Patients in control group received routine therapy, and patients in fluorouracil group received fluorouracil implants implanted in major pectoral muscle and axillary fossa. The counting of leucocyte, bilirubin, ALT, Cr, the drainage of the incision, the incidence of subcutaneous fluid, local ulceration were observed. Results There were no significant differences in the counting of leucocyte, bilirubin, ALT, Cr, the drainage of the incision, the incidence of subcutaneous fluid, and local ulceration between the two groups (P > 0.05), but there existed significant changes after the surgery in the two groups (P < 0.05). Conclusion The application of fluorouracil implants in patients with breast cancer is safe, effective, and convenient, and might become a new promising method to prevent post-operative local recurrence of breast cancer.更多还原