【摘要】 目的探讨血清胆汁酸(total bile acids,TBA)活性、天门冬氨酸氨基转移酶(aspartate aminoxansferase,AST)与丙氨酸氨基转移酶(alanine aminotransferase,ALT)的比值(AST/ALT)在肝病诊断和鉴别诊断中的临床意义。方法选择本院住院肝病患者169例(急性肝炎38例、慢性肝炎65例、肝硬化45例、原发性肝癌21例),采用东芝TBAI-120RF全自动生化分析仪测定健康人和肝病患者血清中TBA、AST/ALT的值,并对结果进行分析和统计学处理。结果各肝病组血清中TBA活性均显著高于正常对照组(P<0.01),且以急性肝炎最高,肝硬化次之,即急性肝炎>肝硬化>原发性肝癌>慢性肝炎,除原发性肝癌组与慢性肝炎组之间差异无统计学意义(P>0.05)外,其余各肝病组之间差异均有统计学意义(P<0.01或P<0.05);肝病组AST/ALT比值与正常对照组间差异均有统计学意义(P<0.01),各肝病组间AST/ALT比值差异均有统计学意义(P<0.01)。结论血清TBA、AST/ALT比值不仅可反映肝细胞受损的情况,还可对肝病的诊断、鉴别诊断、疗效观察及预后判断提供依据。更多还原

【Abstract】 Objective To explore the clinical significance of serum total bile acid and AST/ALT ratio in the diagnosis and differential diagnosis of liver diseases.Methods One hundred and sixty-nine patients with liver diseases hospitalized in our hospital(38 cases of acute hepatitis,65 cases of chronic hepatitis,45 cases of liver cirrhosis,and 21 cases of primary liver cancer) were involved in this study.The serum total bile acids values and AST/ALT ratios in these patients were tested by automated biochemical analyzer model TBA-120RF.And the results were statistically analyzed.Results The level of serum TBA in each liver disease group was significantly higher than that of normal control group(P<0.01),moreover,the acute hepatitis group had the highest level of TBA,followed by liver cirrhosis group,primary liver cancer group,and chronic hepatitis group.No statistically significant difference was found in the level of serum TBA between primary liver cancer group and chronic hepatitis group(P>0.05),but the difference was statistically significant among the other liver diseases groups(P<0.01 or P<0.05).There were statistically significant differences in the AST/ALT ratio between normal control group and each liver disease group(P<0.01).There were statistically significant differences in the AST/ALT ratio among liver diseases groups(P<0.01).Conclusions The serum TBA level and AST/ALT ratio not only reflect the severity of liver disease,but also provide a valuable basis for the diagnosis of liver diseases,differential diagnosis,efficacy observation,disease monitoring and prognosis.更多还原