【摘要】 目的探讨0.03%他克莫司软膏治疗眼睑部皮炎的疗效。方法 26例患者外用0.03%他克莫司软膏,2次/d,共2周。于治疗前及治疗后第3天,第1、2周和停药后1月各随访1次。结果 26例患者治疗后3天、1周、2周及停药1个月后临床痊愈率分别为57.69%,76.94%,92.30%,73.08%。对红斑、瘙痒的控制起效迅速,而脱屑及肥厚改变较缓。4例(15.38%)患者局部有灼热感,均发生在治疗初3天。停药1个月后共有7例(26.92%)患者复发。结论 0.03%他克莫司软膏治疗眼睑部皮炎起效快,疗效明显,长期使用的安全性需大样本观察研究。更多还原

【Abstract】 Objective To investigate the clinical efficacy of 0.03% tacrolimus ointment in patients with atopic blepharitis.Methods Twenty-six patients were treated with 0.03% tacrolimus ointment twice a day for 2 weeks,and the clinical symptom and sign scores were recorded before and after treatment.Results The clinical cured rate was 57.69%,76.94%,92.30% and 73.08% at the 3th day,7th day,14th day and 30th day after treatment respectively.Among a variety of skin lesions,the therapeutic effect was better for erythema and itching than that for xerosis cutis and thickening.Four cases(15.38%) were reported to have local burning,which all happened in the first 3 days of treatment.There are 7(26.92%) patients who recurrent after withdraw of the treatment.Conclusion 0.03% tacrolimus ointment is an effective treatment option for the patients with atopic blepharitis.Long-term efficacy and safety of the medicine have to be evaluated by long-term follow-up studies.更多还原