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鳞盖红菇菌丝体多糖对H22荷瘤小鼠Bcl-2和P53表达的影响

Effect of Russula lepida Mycelial Polysaccharide on the Expression of Bcl-2 and Mutant P53 Proteins in H22 Liver Tumor-Bearing Mice

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【Author】 ZHANG Kun1,ZHANG Wei2,ZHAO Yongxun3,YANG Chunjia1, SHAO Mingliang4,LI Shumin2 1Basic Medical College of Jiamusi University,Jiamusi,Heilongjiang 154007,China;2Laboratory Department of Jiamusi University,Jiamusi,Heilongjiang 154002,China;3Life Science College of Jiamusi University,Jiamusi, Heilongjiang 154007,China;4Maternal and Child Care Hospital of Jiamusi,Jiamusi,Heilongjiang 154002,China

【机构】佳木斯大学基础医学院；佳木斯大学检验学院；佳木斯大学生命科学学院；佳木斯妇幼保健院；

【摘要】用鳞盖红菇(Russula lepida)菌丝体多糖连续灌胃H22荷瘤小鼠10d。与阴性对照组相比,多糖组的瘤重降低,Bcl-2和突变型P53的表达下调,表明鳞盖红菇菌丝体多糖对H22荷瘤鼠有抑瘤作用,可以抑制H22肝癌细胞的增殖。更多还原

【Abstract】 H-22 liver tumor-bearing mice were administered physiological saline intragastrically(negative control),5-flurouracil intraperitoneally(positive control) or Russula lepida mycelial polysaccharide intragastrically(test group) and sacrificed after 10 days.Our data revealed that R.lepida mycelial polysaccharide inhibited tumor growth and that proliferation of the cancer cells was due to decreased expression of Bcl-2 and mutant P53 proteins.更多还原

【关键词】鳞盖红菇；多糖； H22荷瘤小鼠；
【Key words】 Russula lepida； mycelial polysaccharide； H22 tumor-bearing mice；

【基金】黑龙江省教育厅科研项目(编号:11544054)的部分研究内容

【文献出处】食用菌学报 ,Acta Edulis Fungi , 编辑部邮箱 ,2011年03期

【分类号】R73-36
【被引频次】7
【下载频次】131

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