【摘要】 目的 探讨3.0T MRI BOLD成像技术在评估正常大鼠肾脏氧代谢的价值。方法 29只SD大鼠麻醉后行3.0T MRI常规及BOLD序列扫描,分别测量大鼠左右肾脏皮质、外髓及内髓的T2^*值,从而计算R2^*值（=1/T2^*值）。结果 正常大鼠左右肾脏皮质R2^*值分别为（28.84±3.11）s^-1及（30.20±3.48） s^-1;外髓R2^*值分别为（32.77±3.07） s^-1及（31.76±2.73） s^-1;内髓R2^*值分别为（28.37±2.80） s^-1及（29.54±2.42） s^-1。结论 磁共振BOLD成像技术可监测肾脏皮髓质氧代谢变化情况,从而评估肾脏疾病的功能损害程度。更多还原

【Abstract】 Objective To evaluate the application of 3.0T MRI in evaluation of the blood oxygen level dependent in the normal mice kidney.Methods 29 SD mice were anesthetized and then underwent MR scanned at 3.0T scanner.The scanning sequences included T₁ WI,T₂WI and BOLD series.The T₂^* values of the cortex,extramedulla and intramedulla of left and right kidney were measured on BOLD series to obtain the R₂^*（=/T2^*） values.Results The R2^* values were（28.84±3.11）s^-1 and（30.20±3.48）s^-1 in cortex of left and right kidneys,（32.77±3.07） s^-1 and（31.76±2.73）s^-1 in extramedulla,（28.37±2.80） s^-1 and（29.54±2.42） s^-1 in intramedulla of left and right kidney,respectively.Conclusion MR BOLD technique can be used in monitor of intra-renal oxygenation status,it is of potential value in clinic application in evaluation of renal functional damage.更多还原