【摘要】 目的探讨AEG-1与CXCR4基因表达对乳腺癌脑转移的影响。方法对1997～2007年收治的乳腺癌患者进行随访,以发生脑转移的33例患者作为病例组,以未发生脑转移的45例患者作为对照组。通过免疫组化法,对照分析AEG-1及CXCR4对脑转移的影响。结果脑转移组中AEG-1及CXCR4的阳性表达率分别为63.6%和60.6%,与其在对照组中表达(31.1%和33.3%)差异显著(P<0.05)。logistic回归分析结果显示,AEG-1和CXCR4回归系数分别为1.242和1.545。结论 AEG-1和CXCR4阳性表达是乳腺癌发生脑转移的独立危险因子,AEG-1及CXCR4有望成为针对乳腺癌脑转移的高特异性早期诊断指标及基因治疗靶点。更多还原

【Abstract】 Objective Explore the effect of AEG-1and CXCR4 gene on brain metastasis in breast cancer.Methods 33 breast cancer patients with brain metastasis and 45 patients without brain metastasis in our hospital from 1997 to 2007 were chosen randomly for the case control study by immunohisto chemical method.Results the expression rate for AEG-1and CXCR4 in the two groups were 63.6%,60.6% and 31.1%,33.3% respectively,with a notebly difference be observed.the regression coefficient for AEG-1 and CXCR4 was 1.242 and 1.545.Conclusion AEG-1 and CXCR4 were independent risk factors and may be specific diagnosis index and gene treatment taget for brain metastasis in breast cancer.更多还原