【摘要】 目的探讨急性白血病(AL)患者血脂[胆固醇(TC),甘油三酯(TG),高密度脂蛋白(HDL)和低密度脂蛋白(LDL)]变化的临床意义。方法采用酶学法检测271例AL患者(初治115例,完全缓解CR 85例,复发71例)的血脂值。结果 AL患者具有低TC、低HDL、低LDL和高TG血症特点,初治、复发的AL患者TC、HDL和LDL值明显低于CR组和对照组(P<0.01),而TG则明显高于CR组和对照组(P<0.01);TC、HDL和LDL值与外周血WBC数及骨髓中白血病细胞数成负相关,TG则与之成正相关(P<0.05);血脂与AL亚型有关,TC、HDL和LDL在M7、M6和L1中较低,TG在M3、L1和L2中较高(P<0.01);难治复发和具有不良预后染色体核型的AL患者初治时血脂代谢紊乱更明显。结论血脂值变化可作为AL诊治过程中判断病情、评估预后的参数。更多还原

【Abstract】 Objective To investigate the clinical significance of serum lipids alteration(total cholesterol,low density lipoprotein,high density lipoprotein and triglyceride) in patients with acute leukemia(AL).Methods Serum lipids of 271 AL patients(including untreated 115,completely remission CR 85 and relapsed 71) were measured by automatic biochemistry analyzer using enzymatic methods.Results AL patients had the characteristics of low TC,low LDL,low HDL and high TG level.The level of TC,LDL and HDL in period of untreated and relapsed were significantly lower than completely remission(CR) and constrast group(P<0.01).But TG were significantly higher than CR and constrast group(P<0.01).The level of TC,LDL and HDL were negatively correlated with peripheral WBC counts and leukemia cells of bone marrow,but TG were positively correlated with them(P<0.05).The level of serum lipids were correlated with AL subtypes,such as TC,LDL and HDL were lower in subtypes of M7,M6 and L1,while TG were higher in subtypes of M3,L1 and L2(P<0.01).The refractory and relapsed AL patients and those with poor prognostic chrosome had more unsteady serum lipids than the others when they diagnosed.Conclusion The level of serum lipids can be considered as important indicators for therapeutic effects and prognosis of AL patients.更多还原