【摘要】 目的:探讨2型糖尿病肾病患者血浆D-二聚体、纤维蛋白原、抗凝血酶Ⅲ的改变及其临床意义。方法:采用TOP全自动血凝分析仪,检测121例2型糖尿病患者和健康对照组36例的血浆D-二聚体、纤维蛋白原浓度和抗凝血酶Ⅲ活性。根据24 h尿蛋白排泄率(UAE)将2型糖尿病患者分为无蛋白尿组(UAE<30 mg/24 h)62例与微量白蛋白尿组(UAE为30～300mg/24 h)59例。结果:2型糖尿病无蛋白尿组D-二聚体、纤维蛋白原含量明显高于健康对照组(P<0.05),抗凝血酶Ⅲ活性两组比较差异无统计学意义(P>0.05);微量白蛋白尿组D-二聚体、纤维蛋白原含量明显高于无蛋白尿组和健康对照组,抗凝血酶Ⅲ活性明显低于无蛋白尿组,差异均有统计学意义(P<0.05)。结论:血浆D-二聚体、纤维蛋白原、抗凝血酶Ⅲ的检测对于2型糖尿病肾病的早期判断以及疾病的早期预防和病情监测有重要意义。更多还原

【Abstract】 Objective: To explore the changes of D-Dimer,fibrinogen and antithrombin-Ⅲ(AT-Ⅲ) in the patients with type Ⅱ diabetic nephropathy(DN) and its clinical significance.Methods: Automatic coagulation analyzer TOP was used to detect the D-Dimer,fibrinogen and antithrombin-Ⅲ(AT-Ⅲ),in 121 type Ⅱdiabetes mellitus patients and 36 controls.The DM groups were divided into non-albuminuria group(UAE<30 mg/24 h,62 patients) and micro-albuminuria group(UAE: 30~300 mg/24h,59patients).Results:Compared with controls,D-Dimer and fibrinogen increased significantly in non-albuminuria group(P<0.05).For the activity of AT-Ⅲ,there was no difference between the non-albuminuria group and the control group(P>0.05).D-Dimer and fibrinogen increased significantly(P<0.05) in micro-albuminuria group,compared with controls and the non-albuminuria.AT-III decreased significantly(P<0.05) in micro-albuminuria group,compared with the non-albuminuria.Conclusions: Detection of D-Dimer,fibrinogen and antithrombin-III(AT-Ⅲ) in the patients with type Ⅱ diabetic,may have certain significance in monitoring early prevention of DN.更多还原