【摘要】 目的:探讨甲亢患者131I治疗前后血清细胞因子水平。方法:用放射免疫分析法检测48例131I治疗的甲亢患者治疗前及治疗后3个月外周血白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的变化。结果:甲亢131I治疗的患者治疗后血清IL-1与对照组及治疗前有差异但无统计学意义;血清IL-6和TNF-α治疗前水平明显高于对照组,治疗后高于对照组;IL-6治疗前水平明显高于治疗后,而TNF-α治疗前水平高于治疗后。结论:131I治疗可影响血清细胞因子的水平。更多还原

【Abstract】 Objective:To study the effects of treated by131I on the serum cytokine levels of patients with hyperthyroidism.Methods:The 48 patients with hyperthyroidism and 40 normal controls were using the method of radioimmunoassay,the levels of inter-leukin-1(IL-1),interleukin-6(IL-6) and tumor necrosis factor(TNF-α) in serum of 48 patients were measured before and after131I therapy,and the results were compared with the control group.Results: The levels of IL-1 hyperthyroidism of before131I therapy were higher than those in the control group and after131I therapy;The levels of IL-6 and TNF-α of hyperthyroidism of before131I therapy were significantly higher than the control group;After131I therapy were higher than the control group;And the serum level of IL-6 of hyperthyroidism before131I therapy was significantly higher than after131I therapy,and the serum level of TNF-α of hyperthyroidism before131I therapy was higher than after.Conclusions: Cytokines have effect on the progressing of hyperthyroidism;131I therapy can inhibit levels in the serum cytokine with hyperthyroidism.更多还原