【摘要】 目的:观察普伐他汀对颅内动脉狭窄的疗效,同时探索颅内动脉硬化好转和卒中复发的危险因素。方法:共纳入60例有大脑中动脉和(或)基底动脉狭窄的住院患者。所有患者予以抗血小板聚集药物,同时予以普伐他汀20mg/d 1年。分别于入院时和1年后行磁共振血管成像(MRA),评价颅内动脉狭窄的程度。主要结局指标是颅内狭窄动脉的变化。结果:1年后,颅内狭窄动脉好转者、稳定者和恶化者分别为34(56.7%)、22(36.7%)和4(6.6%)例。女性患者动脉狭窄好转的可能更大(P<0.05)。有10例(16.7%)患者脑卒中复发。有43条(53.1%)狭窄动脉有不同程度的改善。结论:普伐他汀对颅内动脉狭窄有较好的疗效,女性患者动脉狭窄好转的可能更大。以后的研究应观察他汀类药物对有颅内动脉狭窄患者的死亡的影响。更多还原

【Abstract】 Objective: To observe the effects of pravastatin on the progression of Intracranial arterial stenosis(IAS),explore the factors associated with atherosclerosis regression and the recurrent rate of stroke.Methods: A hospital-base observation study enrolled 60 stroke patients with middle cerebral artery(MCA) or/and basilar artery(BA) stenosis.All patients were given pravastatin 20mg per day for at least one year.All patients were also given antiplatelet agents for stroke prevention.IAS was assessed by magnetic resonance angiogram(MRA) at the time of enrollment and then at least one year later.The primary outcome was the progression of IAS.Results: At the end of the study,34(56.7 %),22(36.7 %) and 4(6.6 %) patients had regressed,stationary and progressed IAS,respectively.Females were likely to have regressed IAS(P=0.014).The recurrent stroke rate was 16.7%.Among the 81 stenotic vessels,43(53.1 %) vessels were assessed as improvement in stenosis.Conclusion: Compared with other studies,more regressed,stationary IAS and less progressed IAS are find in our study.Female gender is likely to have regressed IAS after statin treatment.Further trials are required to assess the effects of pravastatin on mortality in this particular group of patients.更多还原