【摘要】 目的 YAP蛋白在膀胱尿路上皮肿瘤中表达及与P53蛋白表达的关系。方法依据2004年WHO肿瘤分类标准对68例膀胱尿路上皮肿瘤进行组织学分级,采用免疫组织化学方法检测68例膀胱尿路上皮肿瘤组织和20例非特异性炎症组织中YAP、P53蛋白的表达。结果 68例膀胱尿路上皮肿瘤中59例(86.8%)YAP表达阳性,而膀胱非特异性炎症组织中YAP呈阴性表达,差异有统计学意义(P<0.05)。YAP在膀胱尿路上皮肿瘤组织中的表达与肿瘤体积相关(χ2=6.22,P<0.05),但在年龄、性别、组织学分级等临床因素间无统计学差异(P>0.05)。P53在该组病例中阳性率为33.8%(23/68)。YAP与P53蛋白的表达具有相关性(r=0.262,P<0.05)。结论大多数膀胱尿路上皮肿瘤组织中表达YAP,并与肿瘤生长密切相关。更多还原

【Abstract】 Objective To investigate the Yes-associated protein(YAP) expression in urothelial tumors of the bladder and its relationship with P53 protein expression. Methods The histological morphology of 68 cases of urothelial tumors of the bladder was reviewed according to the WHO/ISUP Classification(2004).The expression of YAP in 68 specimens of urothelial tumors of the bladder and 20 specimens of non-specific inflammation tissue was detected by immunohistochemistry. Results Positive rate of YAP was 86.8% in 68 urothelial tumors of the bladder,while no expression of YAP was detected in non-specific inflammation bladder tissues.YAP expression was significantly different between two groups(P<0.05).YAP expression was correlated with gross tumor volume(χ2 =6.22,P<0.05),but not with the age,sex and histology grading(P>0.05).The expression rate of P53 protein was 33.8%(23/68)in 68 cases of urothelial tumors of the bladder.Statistical analysis showed a correlation between YAP and p53(r=0.262,P<0.05). Conclusion YAP expression can be detected in the majority of urothelial tumors of the bladder,and its expression may be closely related with tumor growth.更多还原