【摘要】 目的探讨灼口综合征(BMS)患者血清IL-6、TNF-α水平,以了解BMS的病因及发病机制,为进一步治疗提供理论依据。方法灼口综合征(BMS)组选择初诊患者22例,其中女性19例,男性3例。对照组为20例年龄、性别相似的健康人。在晨9:00平和状态下抽空腹静脉血2 ml,采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)双抗体夹心法检测血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,对所有数据进行统计分析。结果 BMS组血清IL-6水平显著低于对照组(P<0.05),两组间TNF-α水平差异无统计学意义(P>0.05)。结论 BMS患者血清IL-6水平下降,可能导致其神经的防御、修复功能降低,有可能为BMS的治疗提供一条新的途径。更多还原

【Abstract】 Objective To investigate the changes of serum IL-6 and TNF-α in patients with burning mouth syndrome(BMS),and to provide a basis for the further treatment.Methods Twenty-two patients first diagnosed as BMS(19 females and 3 males) were enrolled.Twenty normal subjects with similar age and sex were chosen as controls.The fasting blood of 2 ml was drawn from the subjects under resting conditions in the morning to examine the serum levels of IL-6 and TNF-α by means of ELISA.The data were statistically analyzed.Results Compared with controls,the serum level of IL-6 significantly decreased in BMS patients(P<0.05),but the level of TNF-α showed no significant change(P>0.05).Conclusion The decrease of IL-6 in BMS patients may reduce the defense of nerve and nerve reparation,which might provide a new treatment way for BMS.更多还原