【摘要】 目的观察抗衰I号方对亚急性衰老小鼠血清MAO-B活性及脑蛋白含量的影响。方法采用D-半乳糖致亚急性衰老小鼠模型。分离脑组织称重计算脑指数;采用紫外分光光度法测定小鼠血清MAO-B活性;考马斯亮蓝测定小鼠脑组织中蛋白含量。结果与模型组比较,抗衰1号方各给药组均能不同程度降低血清中MAO-B活性(P<0.05),增加脑蛋白含量(P<0.05),对脑指数无显著性影响。结论抗衰I号方抗衰老作用机理可能与其降低血清MAO-B活性,提高脑蛋白含量有关。更多还原

【Abstract】 Objective:To observe the effect of Anti-aging I prescription on the activity of serum MAO-B and the content of brain protein in subacute aging mice.Methods: The subacute mice model was made with D-galactose.The brain tissue was separated to weigh the brain index.Ultraviolet spectrophotometry was applied to determine the activity of serum MAO-B.The content of brain protein was determined with Coomassie Brilliant Blue.Results: Compared with the model group,the activity of serum MAO-B in the groups treated with Anti-aging I prescription decreased in varying degrees(P<0.05),and the content of brain protein also improved(P<0.0of 5).Conclusion: The anti-aging mechanism of Anti-aging I prescription may be that it can reduce the activity of serum MAO-B,and improve the content brain protein.更多还原