【摘要】 目的:研究不同卡马西平(CBZ)血清药物浓度对治疗部分性癫痫患者疗效的影响,为相关治疗提供参考依据。方法:按预期血药浓度控制水平将124例部分性癫痫患者随机分为高血药组即A组(卡马西平血药浓度:9～12μg/ml)和低血药组即B组(卡马西平血药浓度:4～8μg/ml),定期进行血药浓度监测,分析两组患者脑电图特征与临床疗效的差异。结果:在有效血药浓度范围内,卡马西平血药浓度增高不能提高临床疗效,对控制脑电图痫样放电也没有明显改善,且可导致背景活动异常。非线性动力学分析结果显示高血药浓度组脑电活动系统稳定性差。结论:卡马西平血药浓度以能控制症状的最低有效浓度即可,增加血药浓度对患者无益。更多还原

【Abstract】 Objective: To study the effects of Carbamazepine(CBZ) serum drug concentration on the therapeutic effectiveness of patients with partial epilepsy in order to provide reference basis for relevant therapies.Methods: 124 patients with partial epilepsy were randomly divided into high serum drug concentration group,i.e.the Group A(the carbamazepine serum drug concentration is 9 to 12μg/ml) and low serum drug concentration group,i.e.the Group B(the carbamazepine serum drug concentration is 4 to 8μg/ml) based on the expected control level of serum drug concentration,monitoring for serum drug concentration was periodically performed,and the difference between the patients of the two groups in the aspect of electroencephalograph characteristics and clinical therapeutic effectiveness was analyzed.Results: The increase of carbamazepine serum drug concentration within an effective serum drug concentration range failed to improve clinical therapeutic effectiveness and brought no significant improvement to the control for epileptiform discharge in electroencephalograph,but could result in abnormal background activity.The results of nonlinear dynamic analysis showed that the system stability of electrical activity of brain in the high serum drug concentration group is poor.Conclusions:The carbamazepine serum drug concentration was preferably at the lowest effective concentration level capable of controlling symptoms,and increasing serum drug concentration was not good for patients.更多还原