【摘要】 目的:探讨E2F-1基因在肺癌中的表达及意义。方法:采用免疫组化S-P法,检测60例肺癌及20例正常肺组织中E2F-1基因蛋白的表达情况。结果:E2F-1在肺癌组织中的阳性率为91.7%,显著高于正常肺组织的10%,两组间差异有显著性(P<0.05);E2F-1与肺癌患者的性别、年龄、组织学类型、分化程度及淋巴结转移等无相关性(P>0.05)。结论:E2F-1的异常高表达在肺癌的发生发展中起重要作用,可作为肺癌基因诊断和治疗的靶点。更多还原

【Abstract】 Objective: To investigate the expression of E2F-1 in lung cancer.Methods: The expression of E2F-1 was detected at their protein level by Immunohistochemistry S-P method in 60 specimens of lung cancer and 20 specimens of normal lung tissue.Results: The positive expression of E2F-1 was 91.7%,which was significantly higher than 10% in normal lung tissues,and there was a signifi-cant difference between the two(P<0.05);there was no relation between the expression of E2F-1 and the characteristics of lung cancer,i.e sex,age,tumor pathological type,differentiation,lymph node metastasis(P>0.05).Conclusion: The expression of E2F-1 may play an important role in the occurrence of Lung cancer,and can be used to gene diagnosis.更多还原