【摘要】 目的:探讨RIP3(受体相互作用蛋白-3)在淋巴瘤患者病理组织中是否表达及其亚细胞定位,并初步观察RIP3的表达是否与淋巴瘤病理恶性度相关。方法:(1)利用免疫组化技术检测48例淋巴瘤和非肿瘤侵润淋巴结病理组织中RIP3表达,并观察RIP3亚细胞定位。结果:(1)RIP3在淋巴瘤患者病理组织中均有表达,其亚细胞定位主要在细胞核,在细胞质中相对弱表达。(2)RIP3表达与淋巴瘤病理恶性度可能存在相关性。结论:RIP3在淋巴瘤患者病理组织中存在阳性表达,为研究RIP3是否与淋巴瘤的发病、临床表现和预后相关,提供了新的探索途径。更多还原

【Abstract】 Objective:To investigate the expression of RIP3(receptor interaction protein-3) in lymphoma patients pathological tis-sues and the sub-cellular localization,and to investigate the relationship of the expression of RIP3 and malignant degree of lymphoma.Methods: The RIP3 expression in 48 cases of the lymphoma and non-neoplastic lymph node pathological tissues was detected by im-munohistochemmistry,and the sub-cellular localization of RIP3 was observed.Results: 1) There were RIP3 expresses in the lymphoma pathological tissues,which mainly located in nucleus but weekly in cytoplasm.2) The expression of RIP3 had a relationship with malig-nant degrees of lymphoma.Conclusion: There was RIP3 expression in lymphoma pathological tissues,which shell new light to the study of mechanism of lymphoma.更多还原