节点文献

RIP3在淋巴瘤患者病理组织中的表达

The Expression of Receptor Interaction Protein-3 in Lymphoma Patients Pathology Organization

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 任建鸿郑文谢彦崔建涛宋玉琴李忠武时云飞林宁晶王小沛涂梅峰应志涛平凌燕刘卫平邓丽娟张晨朱军

【Author】 REN Jian-hong,ZHENG Wen,XIE Yan,CUN Jian-tao1,SONG Yu-qin,LI Zhong-wu2,SHI Yun-fei2,LIN Ning-jing,WANG Xiao-pei,TU Mei-feng,YING Zhi-tao,PING Ling-yan,LIU Wei-ping,DENG Li-juan,ZHANG Chen,ZHU Jun(Key Laboratory of Carcinogenesis and Translation Research(Ministry of Education),Department of Lymphoma,1 Oncology molecular biology lab,2Department of Pathology,Peking University School of Oncology,Beijing Cancer Hospital and Institute,Beijing 100142,China)

【机构】 北京大学临床肿瘤学院北京肿瘤医院北京市肿瘤防治研究所淋巴肿瘤科恶性肿瘤发病机制及转化研究教育部重点实验室北京市肿瘤防治研究所肿瘤分子生物学实验室北京市肿瘤防治研究所病理科

【摘要】 目的:探讨RIP3(受体相互作用蛋白-3)在淋巴瘤患者病理组织中是否表达及其亚细胞定位,并初步观察RIP3的表达是否与淋巴瘤病理恶性度相关。方法:(1)利用免疫组化技术检测48例淋巴瘤和非肿瘤侵润淋巴结病理组织中RIP3表达,并观察RIP3亚细胞定位。结果:(1)RIP3在淋巴瘤患者病理组织中均有表达,其亚细胞定位主要在细胞核,在细胞质中相对弱表达。(2)RIP3表达与淋巴瘤病理恶性度可能存在相关性。结论:RIP3在淋巴瘤患者病理组织中存在阳性表达,为研究RIP3是否与淋巴瘤的发病、临床表现和预后相关,提供了新的探索途径。

【Abstract】 Objective:To investigate the expression of RIP3(receptor interaction protein-3) in lymphoma patients pathological tis-sues and the sub-cellular localization,and to investigate the relationship of the expression of RIP3 and malignant degree of lymphoma.Methods: The RIP3 expression in 48 cases of the lymphoma and non-neoplastic lymph node pathological tissues was detected by im-munohistochemmistry,and the sub-cellular localization of RIP3 was observed.Results: 1) There were RIP3 expresses in the lymphoma pathological tissues,which mainly located in nucleus but weekly in cytoplasm.2) The expression of RIP3 had a relationship with malig-nant degrees of lymphoma.Conclusion: There was RIP3 expression in lymphoma pathological tissues,which shell new light to the study of mechanism of lymphoma.

【关键词】 RIP3淋巴瘤病理免疫组化
【Key words】 RIP3LymphomaPathologyImmunohistochemmistry
  • 【文献出处】 现代生物医学进展 ,Progress in Modern Biomedicine , 编辑部邮箱 ,2011年17期
  • 【分类号】R733.1
  • 【被引频次】2
  • 【下载频次】163
节点文献中: 

本文链接的文献网络图示:

本文的引文网络