【摘要】 血管再生在血管发展和内环境的稳定中起重要作用。错乱的血管再生导致多种疾病,如肿瘤和缺血性疾病。近年来研究证实,MicroRNAs在血管再生及调控内皮细胞功能中起重要作用,如miR-126在内皮细胞中特异性表达并调控血管生成;miR-210在缺氧导致的血管生成及内皮细胞存活中发挥重要作用;miR-17~92簇在体外可以抑制内皮细胞的增殖及在基质胶中抑制血管管腔的形成;miR-378、miR-296、miR-21和miR-31可促进肿瘤血管发生等。深入研究血管microRNAs的体内功能,将为有效抑制血管再生,改变血管病理发展提供一种新的治疗策略。更多还原

【Abstract】 Angiogenesis is critical in vascular development and homeostasis.Aberrant angiogenesis leads to a variety of diseases,such as cancer and ischemia.Recent studies have revealed important roles of microRNAs in angiogenesis and endothelial cell(EC) function.For example,miRNA-126 shows EC-specific expression and regulates angiogenesis;miR-210 is a crucial regulator of angiogenesis and EC survival in response to hypoxia;inhibition of miR-17~92 in vitro represses EC sprouting and tube formation in matrigel;miR-378,miR-296,miR-21 and miR-31 contribute to tumor angiogenesis and so on.The further study of angiomiRs function in vivo will support a new therapeutic approach in the active suppression of angiogenesis and the settings of pathological vascularization.更多还原