【摘要】 目的:探讨急性心肌梗死(AMI)患者血浆N末端B型尿钠肽前体(NT-proBNP)的水平与心肌缺血及预后的关系。方法:98例急性心肌梗死患者根据患者是否行直接PCI手术治疗,分为PCI手术治疗组和非PCI治疗组,观察缺血改善情况与NT-proBNP水平的关系,同时根据治疗后NT-proBNP的水平分为三组,A组NT-proBNP<125pg/ml、B组125pg/ml≤NT-proBNP<450pg/ml、C组NT-proBNP≥450pg/ml,观察NT-proBNP的水平与预后的关系。结果:行PCI组NT-proBNP的水平下降程度(438.3±134.5)明显高于未行PCI组者(158.6±146.1,P<0.05),MACE的发生情况C组明显高于A组(P=0.006<0.01),也高于B组(P=0.028<0.05),A组与B组相比,B组的MACE发生率有上升的趋势,但是无统计学意义(P=0.432>0.05)。结论:急性心肌梗死患者早期血浆NT-proBNP的水平在一定程度上可以反应心肌的缺血程度,且与患者的预后成明显的负相关。更多还原

【Abstract】 Objective: To study the relationship between plasma N-terminal pro-B-type natriuretic(NT-proBNP) levels and myocardial ischemia,prognosis in Acute myocardial infarction(AMI) patients.Methods: According to the patients whether underwent primary PCI operation,98 AMI patients were divided into surgical PCI treatment group and the non-PCI treatment group,to observe the association improved schemia situation with NT-proBNP level,meanwhile according to the levels of the NT-proBNP after treatment,the patients were divided into three groups,including A group(NT-proBNP<125pg/ml),B group(125pg/ml≤NT-proBNP<450pg/ml) and C group(NT-proBNP≥450pg/ml),to observe the relationship between the levels of the NT-proBNP and prognosis.Results: The NT-proBNP levels in PCI treatment group decreased significantly(438.3±134.5)compared with non-PCI treatment group(158.6 ± 146.1,P <0.05),The incidence of MACE in group C was significantly higher than group A(P = 0.006<0.01),also higher than the B group(P=0.028<0.05),The incidence of MACE in group B was higher than group A,but the two groups no significant difference in meaning.Conclusions: AMI patients with early plasma NT-proBNP levels Can reflect the degree of myocardial ischemia to some extent,and have a significant negative correlation to prognosis of the patient.更多还原