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共轭亚油酸降血脂及抗动脉粥样硬化作用的研究
Effect of Conjugated Linoleic Acid in Lowering Blood Lipids and Anti-atherosclerosis
【摘要】 目的:探讨共轭亚油酸降血脂及抗动脉粥样硬化形成的作用机制。方法:选用大鼠随机分为正常对照组,高脂模型组,c9,t11CLA:t10,c12CLA=2:1、1:1、1:3、1:6,只含t10,c12CLA共7组。实验至第8周末取血,检测血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和丙二醛(MDA)、超氧化物歧化酶(SOD)活性。结果:与高脂模型组比较,共轭亚油酸组大鼠血清TC、TG、MDA含量明显降低,HDL、SOD含量明显提高(P<0.05)。结论:共轭亚油酸具有降低血脂和抗动脉粥样硬化的作用。
【Abstract】 Objective:To investigate the mechanism of hyperlipoidemia andanti-atherosclerosis effects by conjugated linoleic acid.Methods:Rats were randomly divided into 7 groups:normal control group,hyperlipidemia model group,c9,t11CLA:t10,c12CLA=2:1,1:1,1:3,1:6,only t10,c12CLA group.8 week after the experiment,the total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL),SOD and MDA in sera were detected.Results:Compared with those in the hyperlipi-demia model rats,the levels of MDA and TC,TG in the sera of rats given with CLA were lower(P<0.05),while the activity of SOD and level of HDL increased(P<0.05).Conclusions:Conjugated linoleic acid could inhibit the hyperlipidemia and prevent the formation of atherosclerosis.
- 【文献出处】 现代生物医学进展 ,Progress in Modern Biomedicine , 编辑部邮箱 ,2011年07期
- 【分类号】R543.5
- 【被引频次】38
- 【下载频次】632