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NKT细胞在动脉粥样硬化中的作用
Roles of NKT cells in atherosclerosis
【摘要】 然杀伤T细胞(natural killer T cell,NKT细胞)是一种特殊的淋巴细胞亚群,具有部分T细胞和NK细胞的特征。与这些细胞不同的是,NKT细胞不仅能够识别醣脂类抗原,还在激活后产生促炎症因子和抗炎症因子。由于这些特性,NKT细胞在炎症和免疫方面的研究越来越热。动脉粥样硬化是一种受免疫调节的炎性疾病,因此对NKT细胞在该疾病中作用的研究也逐渐开展起来。
【Abstract】 Natural killer T cell(NKT cell) is a specialized subset of lymphocytes,which shares with some characteristics of both T cell and Natural kill cell(NK cell).Nevertheless,unlike both of them,NKT cell can recognize glycolipid antigens,and produce some pro-inflammatory and anti-inflammatory cytokines on activation.Due to these characteristics,more and more researches about NKT cells in inflammatory and immune aspects are turned up.It is becoming very clear that atherosclerosis is a chronic inflammatory disease with both innate and adaptive immunity in pathological mechanism.Therefore,researches on roles of NKT cell in the disease are getting hot.
【Key words】 NKT cell; Immune response; Two-way adjustment; Atherosclerosis;
- 【文献出处】 现代生物医学进展 ,Progress in Modern Biomedicine , 编辑部邮箱 ,2011年01期
- 【分类号】R543.5
- 【下载频次】209