【摘要】 目的:研究沙棘果的抗炎镇痛及耐缺氧抗疲劳作用。方法:二甲苯法和扭体法研究抗炎镇痛作用,游泳实验和耐缺氧实验研究抗疲劳及耐缺氧作用。结果:沙棘果提取物具有显著镇痛作用(p<0.01),水提物较醇提物效果明显,沙棘果醇提物有抗炎作用(p<0.05),而水提物作用不明显;沙棘果提取物能增强小鼠的抗疲劳能力和耐缺氧能力(p<0.05)。结论:沙棘果具有镇痛抗炎作用及增强小鼠耐缺氧能力和抗疲劳能力,且呈剂量-效应关系。更多还原

【Abstract】 Objective: To study the anti-inflammatory and analgesic effect of extract of Hippophae Rhamnoides fruit and the effect on anti-hypoxia and anti-fatigue in mice.Methods: The rat ear edema induced by dimethyl benzene and writhing in rats to study anti-inflammation effect and analgesic effect,the hypoxia bearing was observed in experimental mice and the swimming test to study the anti-fatigue effect.Results: The extract of the Hippophae Rhamnoides fruit had analgesic effect( p <0.01) ,and water extract was better than the alcohol extract,the alcohol extract had antifatigue effect ( p < 0.05) and water extract hadn’t the effect,the extract of the Hippophae Rhamnoides fruit had hypoxia tolerance and anti-fatigue effect.Conclusion: The Hippophae Rhamnoides fruit had remarkable antiinflammatory effect,analgesic,antifatigue and hypoxia tolerance effect,and it had dosagedomino effect.更多还原