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膜分离技术应用于霉酚酸生产的工艺研究

Study on Mycophenolic Acid Production with Membrane Separation

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【作者】 张斌王普

【Author】 Zhang Bin1,2,Wang Pu1 1(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310032,China) 2(Zhejiang Hisun Pharmaceutical Co.Ltd.,Taizhou 318000,China)

【机构】 浙江工业大学药学院浙江海正药业有限公司

【摘要】 研究了采用多种膜分离技术生产霉酚酸的工艺。通过陶瓷膜、超滤膜、纳滤膜的组合试验,对膜组件进行了筛选,得到了优化的试验方案。通过工艺优化,霉酚酸收率提高至65%~70%,有机溶剂用量减少70%,溶剂损耗减少80%以上,大幅度降低了生产成本,简化了生产工艺,提高了产品的收率和质量,使工艺过程更安全,环保。

【Abstract】 Several membrane separation techniques,including ceramic membrane,ultrafiltration membrane and nanofiltration membrane,have been studied on mycophenolic acid production.The optimized conditions have been obtained.This method simplifies the mycophenolic acid production process,enhances product purity and yield,and promotes the benefit of environmental safety.The yield is increased to 65%~70%,the input organic solvent is reduced by 70%,and the usage of organic solvent was decreased by 80%,so the production cost was significantly reduced.The method also presents great application value under the current policies which advocate resource conservation,green production,and sustainable development.

  • 【文献出处】 食品与发酵工业 ,Food and Fermentation Industries , 编辑部邮箱 ,2011年07期
  • 【分类号】TQ927
  • 【被引频次】4
  • 【下载频次】275
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