【摘要】 沉默信息调节因子1(silent information regulator1,SIRT1)作为NAD+依赖的脱乙酰基酶,参与基因转录、能量代谢以及细胞衰老过程的调节。近年研究显示,SIRT1具有明显的神经保护作用。但SIRT1在阿尔茨海默病(Alzheimer’s disease,AD)中如何发挥对神经元的调节及保护作用仍不甚明了。本文结合近年的研究,重点总结了SIRT1在AD中的神经保护作用及其可能的分子机制,为防治神经退行性疾病提供新思路。更多还原

【Abstract】 Silent information regulator 1 (SIRT1), an NAD + -dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer’s disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.更多还原