【摘要】 目的:探讨血中性粒细胞/淋巴细胞比值(NLR)检测在子宫内膜异位疾病和子宫肌瘤的应用价值及意义。方法:研究对象为在我院手术并经术后病理检查证实的子宫腺肌病102例(子宫腺肌病组)、子宫内膜异位症47例(子宫内膜异位症组)和子宫平滑肌瘤80例(子宫肌瘤组),以及在此期间健康体检的正常妇女72例(对照组)。检测所有患者术前及对照组患者体检时的血NLR、白细胞数、淋巴细胞数、CA125、CA199值,并比较分析,评价NLR、CA125及CA199在3种疾病的诊断敏感性。结果:3种疾病组血NLR值均明显高于对照组(P<0.05或P<0.01)。3种疾病组血NLR比较差异无统计学意义(P>0.05)。子宫内膜异位症组Ⅲ、Ⅳ期患者的血CA125值及阳性率明显高于Ⅰ、Ⅱ期患者,两者差异均有高度统计学意义(P<0.01),但各期间血NLR及CA199值及阳性率差异无统计学意义(P>0.05)。结论:NLR在子宫腺肌病、子宫内膜异位症和子宫肌瘤都显著升高,表明免疫抑制是这3种疾病的共性。血NLR、CA125及CA1993种血清指标联合检测对这3种疾病的鉴别诊断有一定的价值。更多还原

【Abstract】 Objective:To explore the clinical significance of neutrophil-to-lymphocyte ratio (NLR) in endometriosis and hysteromyoma.Methods:102 cases of adenomyosis (adenomyosis group) and 47 cases of endometriosis (endometriosis group), and 80 patients with hysteromyoma (hysteromyoma group), which were confirmed by pathological examination after operation, as well as 72 normal women (control group) in our hospital were enrolled in this study. NLR, leucocyte number, lymphocyte number and CA125, CA199 in serum of all patients before operations were detected and compared with the normal control group. The sensitivity of NLR, CA125 and CA199 in above three diseases was evaluated.Results:Blood NLR level in three diseases were significantly higher than that in control group (P<0.05 or P<0.01). There was no statistical difference about the sensitivity of NLR in the diagnosis of above there disease (P>0.05). The value of CA125 and positive rate in stage Ⅲ and Ⅳ endometriosis were significantly higher than stage Ⅰ and Ⅱ. There was significantly statistical difference (P<0.01). However, there was no statistical difference about the value of CA199 and NLR as well as the positive rate in all stages(P>0.05).Conclusions:NLR in adenomyosis, endometriosis and hysteromyoma is increased significantly, which reflects that immune suppression is the commonness of these three diseases. There is a certain value to detect blood NLR, CA125 and CA199 in the differential diagnosis of these three diseases.更多还原