【摘要】 目的探讨普罗布考对高脂血症大鼠血管内皮功能的影响。方法 50只SD大鼠随机分成5组:对照组(A组)、高脂饲料组(B组)、高脂饲料+VitD3组(C组)、高脂饲料+普罗布考组(D组)、高脂饲料+普罗布考+VitD3组(E组)。第16周时对大鼠行血流动力学研究,并取血检测血清TG、TC、HDL-C、LDL-C、NO、一氧化氮合酶(NOS)、总抗氧化能力(T-AOC)、丙二醛(MDA);最后取主动脉制成病理切片,行HE染色。结果与对照组比较,B组TG、TC、LDL-C、NO、NOS水平升高(P均<0.01),HDL-C水平降低(P<0.01);与未干预组比较,普罗布考干预组NO、NOS、T-AOC水平均升高(P<0.05),TC、HDL-C、LDL-C、MDA水平降低(P<0.05)。血流动力学监测,仅C组大鼠输入硝普钠后血压下降大于输入乙酰胆碱(P<0.05)。结论普罗布考可以改善动脉粥样硬化大鼠内皮依赖性舒张功能不全。更多还原

【Abstract】 Objective To study the effects of probucol on the endothelial function of hyperlipidemia rats.Methods Fifty SD rats were randomly divided into 5 groups: the control group(group A),high fat diet group(group B),high fat diet+VitD3(ip) group(group C),high fat diet+probucol group(group D),high fat diet+VitD3(ip)+probucol group(group E).At the 16th week,the hemodynamic study was performed,then blood samples were collected for the tests of TG,TC,HDL-C,LDL-C,NO,NOS,T-AOC,MDA activity.Then arteriae aortas were collected for HE staining.Results In high fat diet groups,the plasma levels of TG,TC,LDL-C,NO,NOS elevated(P<0.01);HDL-C level decreased(P<0.01).In probucol intervened rats,the plasma levels of NO,NOS,T-AOC elevated(P<0.05),while TC,HDL-C,LDL-C,MDA levels decreased(P<0.05).At the end of study,the extent of blood pressure decreasing after infusing sodium nitroprusside was significantly higher than acetylcholine in group C(P<0.05).Conclusion Probucol can improve endothelium-dependent vascular relaxation dysfunction.更多还原