【摘要】 目的探讨NFκ-B、基质金属蛋白酶(MMP)-1基/质金属蛋白酶抑制剂(TIMP)-1表达在椎间盘退变过程中的作用。方法应用免疫组织化学方法和ELISA方法检测38例椎间盘退变所致腰椎间盘突出症患者退变椎间盘髓核组织(观察组)和8例腰椎爆裂骨折患者的正常椎间盘髓核组织(对照组)中NFκ-B、MMP-1、TIMP-1的表达,计算MMP-1与TIMP-1的比值。结果观察组的NFκ-B表达及MMP-1/TIMP-1均明显高于对照组,P均<0.05。结论 NFκ-B、MMP-1/TIMP-1在腰椎间盘退变过程中起重要作用。更多还原

【Abstract】 Objective To investigate the roles of the expression of nuclear factor kappa B(NF-κB),matrix metalloproteinases-1(MMP-1) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the degeneration of intervertebral disc.Methods Tirty-eight patients with intervertebral disc degeneration from surgical intervention for cervical disc herniation(observed group) and 8 cases of normal disc tissue(control group) were involved,the expression of NF-κB,MMP-1 and TIMP-1 in disc-tissue were tested by immunohistochemistry method and ELISA,the MMP-1/TIMP-1 was calculated.Results The expression of NF-κB,MMP-1/TIMP-1 in observed group were both higher than those in the control group,both P<0.05.Conclusion NF-κB and MMP-1/TIMP-1 may have important effects in the process of intervertebral disc degeneration.更多还原