【摘要】 目的研究肿瘤耐药相关基因MRP3、GST-π在食管鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法应用免疫组化法检测76例食管鳞状细胞癌患者MRP3、GST-π的表达,同时回顾性研究这些表达与食管鳞状细胞癌发生、浸润及转移等临床病理参数的关系。应用Kaplan-Meier生存曲线和Cox回归模型分析其与患者预后的关系。结果食管鳞状细胞癌组织中,MRP3在不同临床分期、有或无淋巴结转移组之间阳性表达率的差异有统计学意义(P<0.05);GST-π在不同临床分期、不同浸润深度组之间阳性表达率的差异有统计学意义(P<0.05)。单因素生存分析表明,MRP3、GST-π阳性表达组的生存率虽低于阴性表达组,但差异无统计学意义(P>0.05)。Cox模型多因素分析表明,肿瘤临床分期是影响生存期的独立因素(P<0.05)。结论检测MRP3、GST-π的表达对食管鳞状细胞癌化疗方案的制定、判断预后有重要的指导意义。更多还原

【Abstract】 Objective To investigate the clinical pathology significance and the expression of MRP3 and GST-π in esophageal squamous cell carcinoma.Methods The immunohistochemical method was used to detect the expression of MRP3 and GST-π in 76 cases of esophageal squamous cell carcinoma.Then to analyse the relationship between the expression of MRP3,GST-π and different clinical pathological factors.The relationship between the expression of MRP3 and GST-π with prognosis of patients was evaluated by Kaplan-Meier survival curve and Cox regression model analysis.Results In different clinical stages and with or without lymph node metastasis of esophageal carcinoma,the positive frequency of MRP3 protein had statistically significant(P<0.05).In different clinical stages and different depth of invasion,the positive frequency of GST-π protein had statistically significant(P<0.05).Univariate survival analysis suggested that the five-year survival rates between the positive and negative frequency groups of MRP3 and GST-π had not statistically significant(P>0.05).Cox multivariate analysis indicated that the TNM stage of esophageal carcinoma was the independent prognostic factor affecting survival rate of patients(P<0.05).Conclusion Examining the MRP3 and GST-π expression in esophageal squamous cell carcinoma plays an important role in orientating the cancer treatment and predicting prognosis.更多还原