【摘要】 目的探讨在人免疫缺陷病毒-1(human immunodeficiency virus-1,HIV-1)感染者中丙型肝炎病毒(hepatitis C virus,HCV)感染对于隐匿性乙型肝炎病毒(hepatitis B virus,HBV)感染的影响。方法研究对象为河南某艾滋病治疗示范区中178例乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阴性的经有偿献血感染HIV-1未经抗病毒治疗的患者,检测项目包括肝功能,HBV及HCV血清标志物,HBV DNA和HCV RNA。分析HIV-1阳性,抗HCV阳性、抗HCV阴性组及HIV-1/HCV感染组中不同HCV RNA载量组HBV病原学检测结果方面的差异。结果 178例HBsAg阴性的HIV-1感染者中,HBV-M全阴性35例;单独抗HBs阳性25例;单独抗HBc阳性51例;HBsAb及HBcAb均阳性34例。抗HCV阳性HIV-1感染者与抗HCV阴性HIV-1感染者的年龄、性别比较差异无统计学意义(P>0.05);丙氨酸转移酶(alanine transaminase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)浓度比较差异有统计学意义(P<0.05);总胆红素(total bilirubin,TBIL)浓度比较差异无统计学意义(P>0.05);乙肝标志物(HBV marker,HBV-M)阴性、单独乙肝表面抗体(hepatitis B surface antibody,HBsAb)阳性、单独乙肝核心抗体(hepatitis B core antibody,HBcAb)阳性、HBsAb及HBcAb均阳性及HBV DNA阳性例数比较差异均无统计学意义(P>0.05)。不同HCV RNA载量患者HBV DNA检测结果比较差异无统计学意义(P>0.05)。结论经有偿献血感染HIV-1人群中,HCV感染及HCV RNA载量高低与隐匿性HBV感染的发生无关;但合并HCV感染可加重HIV-1感染者的肝功能损害。更多还原

【Abstract】 Objective To investigate the influences of HCV infection on occult HBV infection in patients infected with HIV-1. Methods The study enrolled 178 HBsAg-negative treatment-naive HIV-1 patients who transmitted by commercial blood donation in an HIV/AIDS CARE site in Henan province.Many parameters were detected,including liver function,HBV serologic markers(HBsAg,Anti-HBs,HBeAg,anti-HBe and anti-HBc),HCV antibody,HBV DNA and HCV RNA.Analyses were performed to compare the differences of HBV etiological markers in anti-HCV+ group,anti-HCV-group and different HCV RNA groups. Results Among the 178 HBsAg-negative HIV-infected patients,35 were HBV-M negative,25 anti-HBs positive only,25 anti-HBc positive only,34 with both anti-HBs and anti-HBc positive.There were no significant differences in ages and gender between anti-HCV+ group and anti-HCV-group(P>0.05).There were significant differences in ALT and AST(P<0.05) but not total bilirubin between anti-HCV+ group and anti-HCV-group.There were no significant differences in HBV-M negative,isolated HBsAb positive only,isolated anti-HBc positive only,anti-HBs and anti-HBc double positive,HBV DNA positive between anti-HCV+ group and anti-HCV-group.There were no significant differences in HBV DNA positive rate between different HCV RNA groups(P>0.05). Conclusion In the HIV-infected patients who transmitted by commercial blood donation,HCV infection and viral loads of HCV RNA had no correlation with incidence of occult HBV infection,but HCV co-infection could aggravate the liver damage.更多还原