【摘要】 目的总结癫痫开颅手术的癫痫灶定位及治疗情况,提供手术治疗的结果与经验。方法回顾性分析2001年6月～2010年12月在我院行开颅手术治疗的顽固性癫痫患者483例,总结这些患者定位技术、癫痫灶位置、手术治疗方法以及1～8年期的随访情况。结果手术结果 Engel I级313例,Ⅱ级73例,Ⅲ级65例,Ⅳ32例。术后出现硬膜外血肿7例,一过性语言功能障碍17例,一过性一侧肢体力弱25例,永久性右上肢偏瘫1例,记忆力明显下降3例,无死亡患者。结论外科手术是治疗难治性癫痫的一种有效方法,手术前准确定位致痫灶是关键步骤。难治性癫痫的多术式外科治疗不但能有效控制癫痫的发作,而且能最大可能地保护大脑皮层的神经元免遭破坏或切除,更多还原

【Abstract】 Objective To share with you the results of surgical treatment and experiences by concluded of the methods of 483 patients’ operative strategy and Intraoperative positioning of epileptic foci in intractable epilepsy.Methods Retrospective analysis of 483 patients of intractable epilepsy from 2001 june to 2011december who underwent epilepsy surgery craniotomy.summaried the technology of positioning epileptic foci,location of epileptogenic lesions,operative strategy and 1～8 year follow-up results.Results The patients’ postoperative effects acording to Engel’s standard were grade I in 313 cases,grade Ⅱ in 73cases,grade Ⅲ in 65 cases,and grade IV in 32 cases.7 cases of postoperative epidueal hematoma,17 cases of transient language dysfunction,25 cases of transient edcline in muscle force,1 case of paralysis of the right upper limb,3 cases of memory loss.No case edad.Conclusion Surgery is a effective treatment for intractable epilepsy.Accurate location of epileptogenic zone and combitation of mutiple epileptic surgical procedures can result in significant improvements in seizure control for intractable epilepsies without structural lesions.更多还原