【摘要】 目的探讨艾司西酞普兰治疗惊恐障碍的临床疗效与安全性。方法将50例惊恐障碍患者随机分为艾司西酞普兰组25例和帕罗西汀组25例进行治疗,疗程为8周,采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定疗效,以不良反应量表(TESS)评定不良反应。结果治疗后两组HAMA和HAMD分值均显著降低,在治疗第1周、第2周末时艾司西酞普兰组评分显著低于帕罗西汀组(P<0.05),在4、68、周时两组减分率差异无统计学意义(P>0.05)。TESS评分两组在治疗期间差异无统计学意义(P>0.05)。艾司西酞普兰组、帕罗西汀组治疗惊恐障碍疗效分别为92%8、8%。结论艾司西酞普兰治疗惊恐障碍患者起效快、疗效好、不良反应少。更多还原

【Abstract】 Objective To investigate the curative effect and security of escitalopram in the treatment of panic disorder.Methods 50 patients with panic disorder were randomly divided into two groups: escitalopram group and paroxetine group.The course of treatment was 8 weeks.Hamilton Rating Scale for Anxiet(HAMA),Hamilton Rating Scale for Depression(HAMD) were used to assess the clinical effect.The side effects were estimated by Treatment Emergent Symptom Scale(TESS).Results The scores of HAMA and HAMA had significantly differences between before and after treatment in two groups.The HAMA score and HAMD score of escitalopram group was significantly lower than paroxetine group at the end of week 1,2,but no significant differences remained after treatment for 4、6、8 weeks.TESS scores had no significant differences throughout the treatment period in two groups.The response rates were 92% and 88% respectively in escitalopram group and paroxetine group.Conclusion Escitalopram is effective and safe as well as less side effect in the treatment of panic disorder.更多还原