【摘要】 目的系统评价利用血清胱抑素C与尿微量白蛋白监测2型糖尿病早期肾损害的作用,探讨临床监测2型糖尿病肾功能的最佳手段。方法通过数据库检索国内相关文献,选择评价纳入研究的方法学和提取有效数据后,按Corhrane协作网提供的Meta分析对其进行定量综合分析。结果共有15篇文献纳入标准,2型糖尿病早期血清胱抑素C异常检出率高于尿微量白蛋白,合并OR值为1.95,95%CI为(1.39,2.75)。结论血清胱抑素C是评价2型糖尿病肾功能的灵敏指标,且稳定性好,有利于肾功能损害的早期筛查。更多还原

【Abstract】 Objective To assess the monitor value of serum cystatin C(CysC) and microalbuminuria(mALB) in early stage diabetic nephropathy.Method Systematic review of various data bases was performed in this study,based on Meta-analysis provided by Cochrane Cooperation Network.Results A total of 852 patients were chosen from 15 literatures met the inclusion criteria.Meta-analysis showed the positive ratio of CysC was significantly higher than that of mALB,with pooled OR 1.92,95% CI(1.39,2.75).Conclusion Serum CysC is a sensitive index for evaluating early kidney dysfunction in diabetes.更多还原