【摘要】 目的探讨胸腔积液肿瘤标志物CEA、NSE和CYFR21-1联检对肺癌的诊断价值。方法检测不同病理类型肺癌患者血清和胸腔积液CEA、NSE和CYFR21-1水平。结果 (1)肺癌组织CEA、NSE和CYFR21-1胸腔积液水平明显高于良性胸腔积液组(P<0.01);(2)肺癌组织CEA、NSE和CYFR21-1胸腔积液水平明显高于血清水平;(3)肺腺癌的CEA、小细胞肺癌的NSE、肺鳞癌的CYFR21-1血清及胸腔积液水平高于其他病理类型肺癌(P<0.01);CEA对肺腺癌,NSE对小细胞肺癌、CYFR21-1对肺鳞癌的诊断灵敏度明显高于其他单项肿瘤标志物(P<0.01);(4)胸腔积液CEA、NSE和CYFR21-1单项检测对肺癌诊断灵敏度明显高于血清(P<0.05);CEA+NSE+CYFR21-1诊断灵敏度明显高于单项肿瘤标志物(P<0.05)。结论胸腔积液CEA、NSE和CYFR21-1联合检测有助于肺癌临床诊断。更多还原

【Abstract】 Aim To investigate the diagnostic value of the combined detection of CEA,NSE and CYFRA21-1 in pleural effusions and serum for diagnosis of lung cancer.Methods The tumor markers of CEA.NSE and CYFRA21-1 in pleural effusions and serum of lung cancer patients were detected.Results The pleural levels of CEA,NSE and CYFRA21-1 in lung cancer patients were significantly higher than those with benign effusion(P<0.01).The pleural levels of CEA,NSE and CYFRA21-1 in the lung cancer patients were significantly higher than those of serum levels(P<0.05).The serum and pleural levels of tumor markers were related to the pathological types of lung cancer.The highest levels of CEA, NSE and CYFRA21-1 were found in patients with adenocarcinoma,small-cell pulmonary carcinoma and squamous carcinoma,respectively(P<0.01).The sensitivity of individual detection of CEA,NSE and CYFRA21-1 in diagnosing lung cancer was higher than that of serum(P<0.05).The sensitivity of combined detection of CEA,NSE and CYFRA21-1 in diagnosing lung cancer was significantly higher than that of individual tumor marker(P<0.05).Conclusion Combined detection of pleural levels of CEA,NSE and CYFRA21-1 and several tumor markers is helpful for diagnosis of lung cancer.更多还原