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1,25-二羟维生素D3对哮喘大鼠血清中Eotaxin及IL-8表达的影响

Effects of 1.25-(OH) 2D3 on expression of Eotaxin and IL-8 in plasma of asthmatic rats

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【作者】 田维敏尚云晓蔡栩栩魏秀清

【Author】 TIAN Wei-min,et al.(Department of Pediatrics,Zhongshan Hospital,Xiamen University,Xiamen,Fujian 361004,the P.R.China.)

【机构】 厦门大学附属中山医院儿科中国医科大学附属盛京医院小儿呼吸内科牡丹江市妇女儿童医院

【摘要】 目的探索1,25-(OH)2D3对哮喘大鼠血清中Eotaxin及IL-8表达的影响。方法 50只Wistar大鼠随机分为正常对照组(N)、哮喘组(A)、1,25-(OH)2D3组(VD)、布地奈德组(B)及1,25-(OH)2D3+布地奈德联合治疗组(L),每组10只。用ELISA法检测血清中Eotaxin及IL-8的表达水平。结果 Eotaxin和IL-8的表达,A组较N组和治疗组明显增高;VD组较A组明显减低,明显高于N组、B组及L组;L组较A组、B组和VD组明显减低。结论哮喘急性发作时血清中Eotaxin及IL-8的表达水平显著增高,1,25-(OH)2D3有效抑制了哮喘时的Eotaxin和IL-8的表达水平,1,25-(OH)2D3与布地奈德联合治疗作用更为明显。

【Abstract】 Objective To investigate the effects of 1.25-(OH) 2D3 on the levels of Eotaxin and IL-8 in the plasma of asthmatic rats.Methods 50 wistar rats were randomly divided into five groups: Normal control group(N),asthma group(A),1.25-(OH)2D3 group(VD),Budesonide group(B),and therapeutic alliance group of 1.25-(OH)2D3 and Budesonide(L).The expressive levels of chemokines of Eotaxin and IL-8 in plasma were detected by ELISA.Results The levels of Eotaxin and IL-8 in plasma were significantly increased in group A than other groups;they markedly decreased in group VD compared with group A,and remarkably higher than group N,group B and group L;and they markedly decreased in group L than in group A,group B and group VD.Conclusions The levels of Eotaxin and IL-8 in plasma of acute episodes of asthma are significantly increased,1.25-(OH)2D3 can efficiently inhibit the levels of Eotaxin and IL-8 in asthma,and the effect of the combination of 1,25-(OH)2D3 and Budesonide could be more significant.

【基金】 沈阳市科学技术计划(项目编号:1081269-9-00)
  • 【文献出处】 齐齐哈尔医学院学报 ,Journal of Qiqihar University of Medicine , 编辑部邮箱 ,2011年23期
  • 【分类号】R562.25
  • 【下载频次】83
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