【摘要】 目的:初步研究3周小剂量多西紫杉醇单药治疗老年激素难治性晚期前列腺癌的疗效并探讨其毒副反应。方法:入选老年激素难治性晚期前列腺癌患者共18例,多西紫杉醇50 mg/m2,静脉滴入,d1;泼尼松5 mg,口服,d1~d21,2次/d,21 d为1个周期。完成4个周期后评价疗效。结果:化疗结束后,6例患者的血PSA值降至正常水平,6例PSA值下降>50%,2例PSA值变化不明显,有效率为66.67%。本组随访2~17个月,中位生存期为12.75个月,疾病进展时间为2个月,1年生存率为33.33%(6/18)。不良反应可耐受。结论:3周小剂量多西紫杉醇单药治疗老年激素难治性晚期前列腺癌有效率较高,毒副反应轻,耐受性好,并可以改善疾病相关症状,提高生存质量。更多还原

【Abstract】 OBJECTIVE: To evaluate the efficacy and toxicity of a single treatment of three-weeks’ small dose docetaxel for elderly patients with advanced prostate cancer.METHODS: Eighteen patients with hormonal refrectory prostate cancer were candidated and given a combination of docetaxel 50 mg/m2 intravenously,d1,and prednisone 5 mg twice a day,d1-d21,21 days as a cycle.Each patient accepted at least for 4 cycles.RESULTS: The patients were followed-up for 2-17 months(mean time 12.75 months),6 of them got a CR,6 PR,and 2 SD.The RR rate was 66.67%.The toxicity of chemotherapy was tolerable.The PPT was 2 months.CONCLUSION: With minor toxicity,the combination of small dose docetaxel plus prednisone has a certain effect on hormone refractory advanced prostate cancer of elderly patients.更多还原