【摘要】 目的:研究EphA2和Ephri-nA1蛋白在乳腺癌组织中的表达及其意义。方法:用免疫组织化学SP法检测130例乳腺癌组织中EphA2和Ephri-nA1的蛋白表达水平及其与临床病理因素的关系。结果:130例乳腺癌组织中,EphA2和EphrinA1蛋白的阳性表达率分别为72.31%和59.23%;EphA2蛋白在乳腺癌的阳性表达率与临床分期、淋巴结转移和组织学分级显著相关,P<0.05。EphrinA1蛋白的阳性表达率与临床分期、组织学分级显著相关,P<0.05。EphA2和EphrinA1蛋白阳性染色共同定位于大致相同的肿瘤区域和血管内皮细胞,两者在乳腺癌组织中的阳性表达显著相关,P<0.05。结论:E-phA2和EphrinA1可能与乳腺癌的发生发展有关。它们的联合检测有助于客观评估乳腺癌的生物学行为,可用来指导临床用药和预测预后。更多还原

【Abstract】 OBJECTIVE:To study the protein expressions of EphA2 and EphrinA1 in breast cancer tissues and to explore their significance.METHODS:Using immunohistochemistry Sp method to detect the protein expressions of EphA2 and EphrinA1 in cancer tissues from 130 breast cancer patients.Then studying their relationship to clinicopathological factors.RESULTS:Among the 130 breast carcinoma cases,The total positive rate of EphA2 and EphrinA1 protein was 72.31% and 59.23%.The positive expression of EphA2 protein were associated with clinical stage,lymph node metastasis and histological grade(P<0.05).The positive expression of EphrinA1 protein were significantly correlated with clinical stage and histological grade(P<0.05).The positive staining of EphA2 and EphrinA1 protein co-located in roughly the same tumor areas and vascular endothelial cells.Their distribution were fundamentally unanimous and their expression were positively correlated(P<0.05).CONCLUSIONS:EphA2 and EphrinA1 may be involved in carcinogenesis and development procedures of breast carcinoma.The combined detection of EphA2 and EphrinA1 can help to predict the clinical and pathologic characteristics of breast carcinoma.It is an important index to guide treatment,and they are predictive factors for breast cancer.更多还原