【摘要】 目的:应用Meta分析法研究行为因素在中国妇女子宫颈癌发病中的危险性。方法:用Review Manger 5.0对国内8篇最近文献的病例-对照研究结果进行固定(FEM)或随机效应模型(REM)的定量综合分析。结果:各因素合并比值比OR(95%CI)分别为:首次性交年龄<20岁,OR=2.32(1.41~3.80);首次怀孕年龄≤21岁,OR=2.96(1.36~6.42);孕次>3,OR=1.93(1.13~3.31);性伴侣数>2,OR=2.18(1.24~3.84);绝经,OR=2.62(1.76~3.91);主动或被动吸烟,OR=2.33(1.46~3.70);教育程度≤9年,OR=3.34(1.53~7.28)。结论:多行为因素Meta分析证实,首次性交年龄<20岁、首次怀孕年龄≤21岁、孕次>3、性伴侣数>2、绝经、主动或被动吸烟及教育程度≤9年与子宫颈癌的发生有关,是子宫颈癌发病的危险因素。而首次性交年龄20~22岁或≥23岁、首次生育年龄≤21岁、产次>2、口服避孕药及居住地与子宫颈癌发病无相关。更多还原

【Abstract】 OBJECTIVE: Behavioral risk factors for cervical cancer in Chinese females were studied using Meta-analysis.METHODS: Eight recently published case-control studies were quantitatively analyzed using fixed effects model(FEM) or random effects model(REM) included in Review Manager 5.0 Package.RESULTS: Pooled odds ratios(OR(95%CI)) for all behavioral factors analyzed were as follows: age at first sexual intercourse <20 years,OR=2.32(1.41-3.80);age at first pregnancy ≤21 years,OR=2.96(1.36-6.42);number of pregnancies >3,OR=1.93(1.13-3.31);number of sexual partners >2,OR=2.18(1.24-3.84);menopause,OR=2.62(1.76-3.91);active/passive smoking,OR=2.33(1.46-3.70);and education received ≤9 years,OR=3.34(1.53-7.28).CONCLUSIONS: Meta-analyses confirmed the following behavioral risk factors for cervical cancer: age at first sexual intercourse <20 years,age at first pregnancy ≤21 years,number of pregnancies >3,number of sexual partners >2,menopause,active/passive smoking,and education received ≤9 years.However,there is no evidence to suggest the following behavioral factors to be risk factors for cervical cancer: age at first sexual intercourse 20-22 or ≥23 years,age at first birth giving ≤21 years,number of births >2,oral contraceptive use,and location of residency.更多还原