【摘要】 目的:研究化疗前应用单一剂量低分子肝素对卵巢癌凝血功能的影响。方法:选择30例卵巢癌患者为单纯化疗组,20例卵巢癌患者为化疗+低分子肝素组,分别检测化疗前和化疗后1、24和48 h血浆纤维蛋白原以及D-二聚体的含量。结果:单纯化疗组化疗后血浆纤维蛋白原含量均低于化疗前,其中化疗后24 h与化疗前相比,差异有统计学意义,P<0.01;D-二聚体水平化疗后显著高于化疗前,其中化疗后24和48 h与化疗前相比,差异均有统计学意义,P<0.01。化疗+低分子肝素组化疗后血浆纤维蛋白原含量也低于化疗前,其中化疗后24和48 h与化疗前相比,差异均有统计学意义,P<0.01;D-二聚体水平化疗后与化疗前相比升高不明显,差异无统计学意义,P>0.05。结论:化疗能显著促进卵巢癌患者凝血和纤溶水平的升高。化疗前应用单一剂量的低分子肝素能抑制凝血功能的活化。更多还原

【Abstract】 OBJECTIVE:To investigate the effect of a single dose of low molecular weight hepatin administered before chemotherapy on blood coagulation of ovarian cancer.METHODS:The changes of plasma fibrinogen and D-dimer in low molecular weight hepatin plus chemotherapy group(n=20) and chemotherapy group(n=30) plasma samples before and after chemotherapy(1 h,24 h,48 h),respectively.RESULTS: The level of fibrinogen after chemotherapy in chemotherapy group was lower than that before chemotherapy,and there was a significant difference between the level 24 h after chemotherapy and that before chemotherapy(P<0.01).The level of D-dimer after chemotherapy was higher than that before chemotherapy,and there was a significant difference between 24 h and 48 h after chemotherapy and before chemotherapy(P<0.01).The level of fibrinogen after chemotherapy in low molecular weight hepatin group was lower than that before chemotherapy,and there was a significant difference between 24 h,48 h after chemotherapy and before chemotherapy(P<0.01).The level of D-dimer after chemotherapy was not higher than that before chemotherapy,and there were no significant differences(P>0.05).CONCLUSIONS: Chemotherapy can promote coagulation and fibrinolysis in ovarian cancer patients.A single dose of low molecular weight hepatin administered before chemotherapy can suppress blood coagulation activation.更多还原