【摘要】 目的探讨多因子诱导的杀伤细胞(CIK)联合白介素-2胸腔内注射治疗癌性胸腔积液的疗效。方法采集15例癌性胸腔积液患者外周血单个核细胞,加入CD3单抗、γ-干扰素、重组人白介素-2诱导成CIK细胞,部分CIK细胞静脉输注,部分CIK细胞联合白介素-2胸腔内注射。结果治疗后患者外周血T细胞亚群的NK细胞(CD1+6CD5+6双阳性细胞)较治疗前明显上升,差异有统计学意义(P<0.05);患者的临床症状、影像学均提示病变较前好转。结论 CIK细胞联合白介素-2胸腔内注射治疗癌性胸腔积液有确切疗效,提高了患者的生活质量。更多还原

【Abstract】 Objective To assess the therapeutic effects of CIK cells and combined intracavitary injection of IL-2 in treating malignant pleural effusion.Methods Peripheral blood mononuclear cells were isolated from 15 patients with malignant pleural effusion.CIK cells were induced by CD3 monoclonal antibody,γ-INF and IL-2 and injected partially via the vein and partially into the thoracic cavity together with IL-2.Results After treatment,peripheral NK cells(CD+16CD+56double positive cells) were increased significantly(P<0.05).Clinical symptoms and iconography of the patients were all improved.Conclusion It is definitely effective to treat malignant pleural effusion with CIK cells and combined intracavitary injection of IL-2,which prolongs the survival and improves the life quality of the patients.更多还原