【摘要】 目的探讨2型糖尿病(T2DM)患者皮质醇水平与高敏C反应蛋白(hs-CRP)的关系。方法以2008年5月—2009年11月在我院内分泌科住院治疗的98例T2DM患者为病例组,按病程分为3个亚组:A组<5年,B组5~14年,C组≥15年;以同期在我院体检的98例健康体检者为对照组。AM 8:00时测定受试对象的血促肾上腺皮质激素(ACTH)、血皮质醇、24 h尿游离皮质醇(UFC)及hs-CRP水平。结果 (1)T2DM组血ACTH、皮质醇和UFC水平均明显高于对照组,差异有统计学意义(P<0.01);(2)T2DM患者血ACTH、皮质醇和UFC水平随糖尿病病程延长而升高,但3个亚组间血ACTH、皮质醇水平间差异无统计学意义(P>0.05);C组UFC水平明显高于A组,差异有统计学意义(P<0.01);C组hs-CRP水平明显高于A、B两组,差异均有统计学意义(P<0.05);(3)偏相关分析显示ACTH、皮质醇、UFC与hs-CRP间无相关关系(r值分别为0.152、0.189和0.118,P>0.05)。结论 T2DM患者血ACTH、皮质醇、UFC、hs-CRP水平较正常人群明显升高,T2DM患者皮质醇水平与hs-CRP无相关关系。更多还原

【Abstract】 Objective To investigate the correlations between cortisol levels and inflammatory reactions in type 2 diabetic(T2DM) patients.Methods Ninety-eight hospitalized patients from our department between May 2008 and November 2009 were enrolled and divided into 3 subgroups according to courses of the disease(group A,less than 5 years;group B,5 years or more but less than 15 years;group C,15 years or more).Meanwhile,98 cases of healthy subjects underwent medical examinations in the same hospital were enrolled as controls.Levels of plasma adreno-cortico-tropic-hormone(ACTH) and Cortisol(Cor),urinary free cortisol(UFC),and high-sensitivity C-reactive protein(hs-CRP) were measured in all subjects at 8 a.m.in the morning.Results Levels of plasma ACTH,Cor,and UFC in the T2DM group were higher than those in the control group with significant differences(P<0.01).Plasma ACTH,Cor,and UFC increased in the T2DM group as the disease course extended.However,no significant differences in plasma ACTH and Cor levels were noted among the three subgroups(P>0.05),while UFC levels in group C were significantly higher than those in group A(P<0.01).CRP levels in group C were significantly higher than those in group A and B(P<0.05).Partial correlation analysis showed that ACTH,Cor,and UFC levels were not correlated with CRP levels.Conclusion Levels of plasma ACTH,plasma Cor,UFC and CRP in type 2 diabetic patients are significantly higher than those in healthy subjects and increase as the disease course extends.Cortisol level in type 2 diabetic patients is not correlated with CRP.更多还原