【摘要】 目的观察瑞芬太尼在腹腔镜胆囊切除术中的应用效果。方法 60例患者随机分成瑞芬太尼组和芬太尼组各30例。术前瑞芬太尼组给予瑞芬太尼,芬太尼组给予芬太尼。10min后2组均给予丙泊酚和琥珀酰胆碱静脉推注诱导。记录2组给用药前、用药后10min、插管、切皮、手术开始后30min及拔管前血压、心率及手术结束至拔管的时间。结果 2组给药前、插管时、切皮和手术30min时收缩压、舒张压和心率比较,差异无统计学意义(P>0.05)。用药后10min和拔管时瑞芬太尼组收缩压均低于芬太尼组,差异均有统计学意义(P<0.05和P<0.01)。瑞芬太尼组平均拔管时间为(6.36±3.29)min短于芬太尼组的(8.79±4.48)min,差异有统计学意义(P<0.05)。结论腹腔镜胆囊切除术中应用瑞芬太尼具有更好的控压效果,降低脑血管意外风险,拔管时间更短,用于短时手术麻醉更具优势。更多还原

【Abstract】 Objective To observe the clinical efficacy of Remifentanil in laparoscopic cholecystectomy.Methods 60 cases were randomly divided into Remifentanil group and Fentanyl group with 30 cases in each.Before operation,Remifentanil group was given Remifentanil,while Fentanyl group was given Fentanyl.10 minites later,both groups were given propofol and succinylcholine iv to induce.BP and HR of before medication,intubation,skin incision,30 minutes after operation and extubation,as well as the time between the end points of operation to extubation of 2 groups were recorded.Results The SBP,DBP and HR of Remifentanil group at the time points of before medication,intubation,skin incision,30 minutes after operation had no statistical significance with those of Fentanyl group(P>0.05).The SBP at the time points of 10 minutes after medication and extubation of Remifentanil group were respectively lower than those of Fentanyl group,and the differences were statistically significant(P<0.05,P<0.01).The average time of extubation of Remifentanil group was (6.36±3.29)min shorter than(8.79±4.48)min of Fentanyl group,and the difference was statistically significant(P<0.05).The difference of other parameter has no statistics significance.Conclusion Remifentanil has better effect of controling blood pressure in laparoscopic cholecystectomy,which can reduce the danger of cerebral vessel,with shorter extubation,so it has more advantage in short time general anesthesia.更多还原