【摘要】 目的观察奥卡西平(OXC)、托吡酯(TPM)单药治疗小儿癫痫的临床疗效和其不良反应(ADR)的发生规律,以提高临床医师对癫痫患儿的用药水平和治疗效果。方法选取该院癫痫患儿138例,随机分为OXC组36例和TPM组102例,其中TPM组又分为低剂量亚组(TPM1组)54例和高剂量亚组(TPM2组)48例。OXC组服用OXC,从8～10mg·kg-1·d-1开始后逐增到l0～30mg·kg-1·d-1,每天2次;TPM组给予TPM,TPM1组从0.625mg·kg-1·d-1开始逐加至治疗剂量,但≤4mg·kg-1·d-1;TPM2组从1.5mg·kg-1·d-1开始加至到8mg·kg-1·d-1为止。结果 OXC、TPM及TPM2组的总有效率分别为80.6%、85.2%和77.1%,差异均无统计学意义(P>0.05)。TPM2组ADR发生率为56.2%(27例)高于TPM1组的33.3%(18例)和OXC组的27.8%(10例),差异均有统计学意义(P<0.05)。结论 TPM和OXC单药治疗小儿癫痫疗效显著,ADR少而轻微,安全性高,依从性好。更多还原

【Abstract】 Objective To master the effect of oxcarbazepines(OXC),topiramates(TPM) single-agent therapy for epilepsy and curative effect of adverse drug reactions(ADR).Methods 138 cases children with epilepsy randomly divided into OXC group(36 cases) and TPM group(102 cases),and TPM group was divided into iow-dose subgroup(TPM1 group,54 cases) and high-dose subgroup(TPM2 group,48 cases).OXC group received OXC from 8～10mg·kg-1·d-1 gradually increased to l0 ～ 30mg·kg-1·d-1,2 times a day;TPM group was given TPM,TPM1 group from 0.625mg·kg-1·d-1 started by adding to the therapeutic dose,but ≤4mg·kg-1·d-1;TPM2 group from 1.5mg·kg-1·d-1 added to the beginning to the 8mg·kg-1·d-1 up.Results The total effectiveness of OXC,TPM and TPM2 groups were 80.6%,85.2%,77.1%,no significant differences in three groups(P>0.05).The incidence of ADR of TPM2 group(56.2%,27 cases) was higher than that in TPM1 group(33.3%,18 cases) and OXC group(27.8%,10 cases)(P<0.05).Conclusion OXC and TPM single-agent therapy for children epilepsyis has a nice effect,light and less ADR,high security and good compliance.更多还原