【摘要】 炎性关节病包括一大类以外周关节炎为主要表现的风湿性疾病,如类风湿关节炎(rheumatoid arthritis,RA)、脊柱关节病(spondyloarthropathy,SpA)及其相关的关节炎,如强直性脊柱炎(ankylosingspondylitis,AS)、银屑病关节炎(psoriaticarthritis,PsA)和炎症性肠病关节炎等。免疫细胞在他们的发病过程中起了重要作用。近年又发现了一种以分泌IL-17为主的辅助性T细胞17(Thelpcell 17,Th17),其介导炎症反应。调节性T细胞(regulatory T cells,Treg)是一类具有免疫抑制作用的T细胞亚群。Th17与Treg细胞在分化过程中是密切相关的,多种细胞因子参与了他们的发育分化过程,Th17/Treg细胞的平衡对维持正常免疫应答、防止自身免疫性疾病具有重要意义。更多还原

【Abstract】 There is a large class of rheumatic diseases which have main manifestation of peripheral arthritis.We could call them inflammatory arthropathy,including rheumatoid arthritis(RA),spondyloarthropathy(SpA) and its related arthritis such as ankylosing spondylitis(AS),psoriatic arthritis(PsA) and inflammatory bowel disease associated arthritis and so on.Immune cells play an important role in their pathogenesis.In recent years,the T help cell 17(Th17) has been found,which mainly secretes IL-17 and mediates inflammatory response.The regulatory T cells(Treg) have immunosuppressive effects.Th17 and Treg cells are closely related in their differentiation process and a variety of cytokines involved.The balance of Th17/Treg cells are important in maintenance of normal immune response and preventing from autoimmune diseases.This paper does a review about the relationship between Th17/Treg cells and the common inflammatory arthropathy.更多还原