【摘要】 通过急性毒性试验、皮肤刺激性试验和细胞毒性试验,对复方阿莫西林纳米乳(AMX-LH-NE)进行体内外安全性评价.结果表明,AMX-LH-NE毒性低,无法测出其半数致死量,小鼠的最大耐受量倍数为426倍;无论是单次给药,还是多次给药,AMX-LH-NE对完整皮肤和破损皮肤均无明显刺激性;AMX-LH-NE为10～150 mg.L-1时,对乳腺上皮细胞的生长和形态无明显影响,其毒性分级属于0或1级,即对乳腺上皮细胞无毒性作用.更多还原

【Abstract】 The safety of compound Amoxicillin and Levofloxacin hydrochloride nanoemulsion(AMX-LH-NE) was evaluated in vivo and in vitro by acute toxicity test,skin irritation test and cytotoxic test.The results showed that the toxicity of AMX-LH-NE was low and its half lethal dose was impossibly measured.The maximum tolerable dose to mice was 426 times.Obvious irritation didn’t appear regardless of single or multiple dosing when AMX-LH-NE was used on complete and damaged skin of rabbits respectively.There was no obvious influence of AMX-LH-NE on growth and appearance of mammary epithelial cells at the concentration of 10 to 150 mg·L-1,and its toxicity grade was 0 or 1.In other words,AMX-LH-NE had no cytotoxicity against mammary epithelial cells.更多还原