Cyr61(cysteine-rich 61),is the first cloned member of the CCN family,produced by growth factor-induction immediate early gene.Acting as an important extracellular,matrix-associated factor,Cyr61 plays an important biological effects in embryonic development,wound repair,the vascular disease and tumorigenesis.The study found that Cyr61 widely express in tumor tissue,and closely related of tumor angiogenesis,and tumor cell proliferation and apoptosis.The expression of Cyr61 in the cell is affected by many kind...