【摘要】 目的:观察心脏再同步化治疗(CRT)对心力衰竭患者血浆脑钠肽(BNP)水平及心功能的影响。方法:选择因顽固性心力衰竭行CRT术患者17人,分别于术前及术后6、12月测定血浆BNP水平,并行超声心动图检查,评估心脏功能。结果:CRT术后6、12个月的血浆BNP水平较术前明显降低(P<0.05),术后6、12个月患者的左室射血分数(LVEF)明显升高(P<0.05),左室舒张末期内径(LVEDD)减小(P<0.05)。Pearson相关分析示,BNP与LVEF呈负相关(r=-0.653,P<0.05),BNP与LVEDD呈正相关(r=0.608,P<0.05)。结论:对于心力衰竭患者,CRT能够明显降低患者的血浆BNP水平,改善其心功能;血浆BNP水平能够反应患者术后心功能情况。更多还原

【Abstract】 Objective:To observe the effects of cardiac resynchronization therapy(CRT) on plasma level of brain natriuretic peptide(BNP) and cardiac function in patients with heart failure.Methods:Seventeen patients with refractory heart failure underwent CRT were enrolled.Plasma levels of BNP were determined before CRT,6 and 12 months after CRT.Cardiac function was evaluated also by echocardiography.Results:Plasma level of BNP was significantly decreased,left ventricular ejection fraction(LVEF) was remarkably increased,while left ventricular end diastolic diameter(LVEDD) was shortened at 6 and 12 months after CRT compared with those before CRT(P<0.05).Pearson analysis showed that BNP was negatively related to LVEF(r=-0.653,P<0.05),and was positively related to LVEDD(r=0.608,P<0.05).Conclusions:CRT might significantly reduce plasma level of BNP and improve cardiac function in patients with heart failure.Plasma level of BNP could reflect patients’ left ventricular function after CRT.更多还原