【摘要】 目的验证非那雄胺间歇给药维持良性前列腺增生(BPH)疗效的可行性并观察间歇给药是否能够减少勃起功能障碍、性欲减退等性功能相关不良反应的发生率。方法收集泌尿外科门诊符合入组条件的60例患者,将受试者均分为3组,分别予非那雄胺(保列治)5 mg 1次/d、1次/2 d及1次/3 d口服,进行为其6个月的随访。以国际前列腺症状评分(IPSS)、生活质量评分(QOL)、前列腺特异性抗原(PSA)、最大尿流率(Qmax)及超声测量作为治疗有效性参数,以勃起功能障碍国际问卷5(IIEF-5)作为治疗前后性功能评价参数。结果 1次/3 d给药组多数患者于试验开始后2~3周出现明显症状加重,提前终止该组实验。随访1次/d及1次/2 d给药组6个月,1次/2 d给药组勃起功能障碍发生率略低于1次/d给药组。结论非那雄胺隔日间歇给药可能能够达到维持BPH疗效、减少药物副反应的目的 ,但这一推断尚需通过更大规模的随机、双盲多中心试验进行证实。更多还原

【Abstract】 Objective To evaluate the outcome of intermittent finasteride for the treatment of benign prostatic hyperplasia(BPH).Methods 60 patients with BPH were equally divided into 3 groups at random,including 1/d,1/2ds and 1/3ds finasteride intaking groups.All the patients were followed up for 6 months.IPSS score,QOL score,serum level of PSA,Qmax,date from ultrasound examination and evaluation of IIEF-5 were observed.Results The study on 1/3ds finasteride intaking group was cancelled ahead of schedule for high incidence of exacerbation.No significant difference was found between the 1/d and 1/2ds groups.Conclusions 1/2ds intermittent finasteride intake may be as effective as daily administration for the treatment of BPH.更多还原