【摘要】 目的:探讨中药生精散对男性不育患者精子DNA损伤的修复作用。方法:选择56例少、弱精子症的不育患者,随机分为中药组和对照组,各28例。中药组服用生精散,对照组服用维生素C及维生素E,治疗1～3个月后复查精液常规及精子DNA碎片指数(DFI),观察两组行IVF-ET周期中获卵数、MⅡ卵子数、受精数、卵裂数、可用胚胎数、种植率、临床妊娠率及流产率。结果:两组治疗前精子密度、活力、活率及DFI值均无显著性差异(P>0.05),治疗后中药组精子活力、活率与治疗前及对照组比较显著提高(P<0.05),DFI值较治疗前及对照组明显下降(P<0.05)。中药组胚胎种植率及临床妊娠率(31.3%vs 15.3%,46.4%vs 21.4%)明显高于对照组(P<0.05),中药组流产率较对照组低(15.4%vs 33.3%)。结论:中药生精散能够明显降低不育患者精子DFI值,提示其能够通过对损伤精子DNA的修复作用,提高精子质量,改善IVF-ET治疗患者的妊娠结局。更多还原

【Abstract】 Objective:To investigate the effect of Shengjing San prescription on sperm DNA repair of infertile patients.Methods:56 patients with oligoasthenospemia were selected and randomly divided into 2 groups as 28 cases for Chinese medicine group and the other 28 cases for control group.The Chinese medicine group were given Shengjing San prescription and the control group were treated with vitamin C and vitamin E.Routine semen exam and sperm DNA fragment index(DFI)were reexamined after 1～3 months of treatment.Observations of retrieved oocyte number in IVF-ET cycle,number of MⅡEgg,number of fertilized eggs,number of cleavage egg,number of available embryos and planting rate,clinical pregnancy rate and abortion rate were carried out in two groups.Results:There is no significant difference in sperm concentration,vitality,and the DFI values between two groups before the treatment(P>0.05).A remarkable improvement were observed in sperm vitality of Chinese medicine group,which compared with control group after the treatment(P<0.05).And there is also a significant decrease in sperm DFI of Chinese medicine group compared with it was in control group and before(P<0.05).Planting rate and clinical pregnancy rate in Chinese medicine group is markablely higher than it in control group(31.3% vs 15.3%,46.4% vs 21.4%,respectively).The abortion rate is lower than that in control group(15.4% vs 33.3%).Conclusion:Shengjing San prescription can remarkably reduce the sperm DNA fragment index of infertile patients,which indicates that it can repair the damaged DNA of sperms to enhance the quality of the sperm so that it can improve the pregnant outcome of the patients undergoing IVF-ET treatment.更多还原