【摘要】 目的通过观察80岁以上患者应用人血白蛋白前后B型钠尿肽(BNP)、中心静脉压(CVP)的变化及相关性,了解胶体溶液对老年人心脏容量负荷的影响。方法入选80岁以上低蛋白血症患者48例,接受人血白蛋白10 g静脉注射治疗,在用药前、用药后24 h分别测定BNP及CVP,并于用药后5 d复查BNP。结果①患者用药前血浆BNP为(150.82±74.90)pg/ml,用药后24 h明显升高至(295.86±193.52)pg/ml(P<0.01)。用药后5 d BNP为(168.25±109.20)pg/ml,较用药后24 h明显下降(P<0.01)。②患者用药前、用药后24 h CVP由(12.08±2.24)cmH2O升至(14.09±2.55)cmH2O(P<0.01)。线形回归分析显示用药后CVP与BNP呈正相关(r=0.46,P=0.015)。③年龄>90岁组用药后24 h血浆BNP明显高于80~90岁组(P<0.01),用药5 d后>90岁组BNP仍明显高于80~90岁组(P<0.05)。结论应用白蛋白对BNP、CVP进行测定可以反映胶体溶液对超高龄患者心脏容量负荷的影响。更多还原

【Abstract】 Objective To observe the changes of B-type natriuretic peptide(BNP)and central venous pressure(CVP)in the elderly patients who received albumin infusion.Methods A total of 48 elderly patients receiving albumin.Plasma BNP and CVP were measured before infusion or 24 hours and 5 days after infusion.Results ① The level of plasma BNP measured 24 hours after infusion was significantly higher(295.86±193.52 pg/ml)than those measured before infusion(150.82±74.90 pg/ml,P<0.01).② CVP measured 24 hours after infusion were significantly higher(14.09±2.55cm H2O)than those measured before infusion(12.08±2.24 cm H2O,P<0.01).There was a significant correlation between plasma BNP and CVP(r=0.46,P=0.015).③ The levels of BNP in >90 years old group were higher than those in 80～90 years old group measured in 24 hours after infusion(P<0.01)and in 5 days after infusion(P<0.05).Conclusion Plasma BNP and CVP could valuably reflect the loading volume of colloid solution in elderly patients.更多还原