【摘要】 目的分析不同临床表现的大脑中动脉狭窄(MCAS)患者的脑血管反应性,探讨其与脑梗死的相关性。方法经经颅多普勒超声(TCD)检测大脑中动脉狭窄患者105例和48例健康对照组,根据症状、体征及脑CT或脑磁共振(MRI)检查将患者分为Ⅰ组(脑梗死组)和Ⅱ组(无脑梗死组),采用TCD屏气试验检测大脑中动脉的屏气指数(HBI),比较Ⅰ组和Ⅱ组与对照组之间的HBI,比较I组和Ⅱ组之间的HBI和血管危险因素。结果Ⅰ组和Ⅱ组的HBI明显低于对照组(P=0.000,P=0.004);Ⅱ组的HBI明显高于Ⅰ组(P=0.000)。Logistic回归分析HBI降低(P=0.000)和高血压(P=0.003)与大脑中动脉狭窄后脑梗死发生密切相关。结论脑血管反应性与脑梗死的发生有关,定期对高血压患者进行TCD及屏气试验监测并进行早期干预,能够预防脑梗死的发生。更多还原

【Abstract】 Objective To assess cerebrovascular reactivity in patients with the different clinical manifestation of middle cerebral artery atherostenosis(MCAS)and to discuss the relation to cerebral infarction.Methods 105patients with MCAS and 48 healthy individuals were detected by transcranial Doppler ultrasound(TCD).According to the symptoms and signs of patients and CT / MRI,patients were divided into group Ⅰ(cerebral infarction group) and group Ⅱ(non cerebral infarction group).The breath-holding index(HBI)of MCA was obtained by TCD and breath-holding test.The HBI was compared among group I,group II and control group.The vascular risk factors were compared between group I and group II.Results Compared with control group,the HBI of group I and group II was markedly low(P=0.000,P= 0.004).However,the HBI of group II was significantly higher than that of group I.The HBI value and hypertension were closely related to the risk of cerebral infarction in patients with MCAS(p=0.000 and p=0.002,respectively) through Logisitic analyse.Conclusions Cerebrovascular reactivity is closely related to the onset of cerebral infarction.If TCD and breath-holding test are regalarily monitored and early treatment is carried on,the happening of cerebral infarction may be prevented.更多还原