【摘要】 目的:探讨膝关节MR软骨成像优化序列。方法:采用3D-FFE-SPIR、3D-FFE-WATS序列对16名健康志愿者行矢状位扫描,计算并比较两种序列下关节软骨、骨髓、滑液、肌肉信噪比(SNR)以及软骨与周围组织间的对比噪声比(CNR)。另外,对52个于检查后1周内做了关节镜(或者手术)检查与治疗的膝关节为观察对象,以关节镜诊断结果为金标准,计算并比较两序列诊断膝关节软骨病变的敏感性、特异性及准确性。结果:两种序列(3D-FFE-SPIR、3D-FFE-WATS)下膝关节软骨SNR值分别为152.07±24.91、131.08±29.21,其数据差异无统计学意义(P>0.05);两序列下骨髓SNR分别为17.27±2.78、19.9±1.95,其数据差异无统计学意义(P>0.05);两序列下滑液SNR分别为73.03±12.25、76.59±12.48,其数据差异无统计学意义(P>0.05);两序列下肌肉SNR分别为90.86±18.62、93.1±18.92,其数据差异无统计学意义(P>0.05)。两序列下软骨/骨髓CNR分别为135.39±22.26,121.88±27.40,其数据差异无统计学意义(P>0.05);不同序列下软骨/滑液CNR分别为79.64±14.32、75.22±18.33,数据差异无统计学意义(P>0.05);两序列软骨/肌肉CNR分别为61.81±9.81、38.91±11.68,数据差异有统计学意义(P<0.05)。3D-FFE-SPIR序列诊断关节软骨病变的敏感性、特异性、准确性分别89.4%、91.7%、93.6%;3D-FFE-WATS序列诊断关节软骨病变敏感性、特异性、准确性分别为90.2%、98.8%、95.2%。结论:3D-FFE-SPIR及3D-FFE-WATS序列是显示膝关节软骨和诊断关节软骨病变的优秀序列,3D-FFE-WATS序列扫描时间比3D-FFE-SPIR序列短、对磁场变化不敏感,因此是膝关节软骨成像的优化序列。更多还原

【Abstract】 Objective:To explore the excellent sequences of knee cartilage imaging.Methods:16 healthy volunteers underwent two sequences 3D(FFE-SPIR,FFE-WATS) scanning to measure the signal intensity(SI) of articular cartilage,bone marrow,synovial fluid,muscles and background and to calculate the signal-to-noise ratio(SNR) and contrast-noise-ratio(CNR).In addition,52 knees accepted the arthroscopy(or surgery) within one week after the examination knee mirrors(or surgery) were taken as the study object,calculating and comparing the diagnostic sensibility,specificity and accuracy of lesions cartilage with the results of the results of arthroscopy(or surgery) as the gold standard.Results:The SNR of cartilage in two sequences(3D-FFE-SPIR,3D-FFE-WATS) was 152.07±24.91,and 131.08±29.21(P>0.05),the SNR of bone marrow was 17.27±2.78,and 19.9±1.95(P>0.05),the SNR of Synovial fluid was 73.03±12.25,and 76.59±12.48,(P>0.05),the SNR of muscle in two sequences was 90.86±18.62 and 93.1±18.92,(P>0.05),the CNR of articular cartilage/ bone marrow was 135.39±22.26 and 121.88±27.40,(P>0.05),the CNR of articular cartilage/Synovial fluid was 79.64±14.32 and 75.22±18.33,(P>0.05).All the above differences were without statistical significance.The CNR of articular cartilage/muscle in two different sequence was 61.81±9.8 and 38.91±11.68,the difference is statistically significant(P<0.05).The sensitivity,specificity,accuracy of diagnosing articular cartilage lesions on 3D-FFE-SPIR was 89.4%,91.7%,and 93.6%.The sensitivity,specificity,accuracy of diagnosing articular cartilage lesions on 3D-FFE-WATS was 90.2%,98.8%,and 95.2%.Conclusion:3D-FFE-SPIR and 3D-FFE-WATS sequences are excellent in showing knee cartilage and diagnosising articular cartilage lesions,the scanning time of 3D-FFE-WATS is shorter than 3D-FFE-SPIR and not sensitive to magnetic field change,therefore,3D-FFE-WATS is the best sequence for knee cartilage imaging.更多还原